A portable surface plasmon resonance biosensor capable of phase interrogation in a large dynamic range

How-Foo Chen; Hsin-Yuan Chuang; Chih-Hang Chen; Yun-Hsiang Chang

doi:10.1117/12.2061732

27 August 2014 A portable surface plasmon resonance biosensor capable of phase interrogation in a large dynamic range

How-Foo Chen, Hsin-Yuan Chuang, Chih-Hang Chen, Yun-Hsiang Chang

Proceedings Volume 9166, Biosensing and Nanomedicine VII; 91660Q (2014) https://doi.org/10.1117/12.2061732
Event: SPIE NanoScience + Engineering, 2014, San Diego, California, United States

Abstract

With the development of a point of care (POC) biosensor in mind, a polymer-molding prism with double parabolic surfaces is invented and developed to implement an ultra-compact SPR biosensor with extremely high sensitivity. The polymer molded parabolic prism is cost effective and disposable, thus cross contamination between biological samples can be avoided. A highly sensitive biosensor with a form factor less than 15cm*15cm*5cm was received with a tunable excitation angle of light beam for a large dynamic range. A highly sensitive optical phase interrogation was demonstrated. The biosensor is also compatible to a modern microscopy platform.

Citation Download Citation

How-Foo Chen, Hsin-Yuan Chuang, Chih-Hang Chen, and Yun-Hsiang Chang "A portable surface plasmon resonance biosensor capable of phase interrogation in a large dynamic range", Proc. SPIE 9166, Biosensing and Nanomedicine VII, 91660Q (27 August 2014); https://doi.org/10.1117/12.2061732

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