27 August 2014 Laser system of the autofluorescence polarimetry of cytological layers at an early stage of cancer detection
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Abstract
A new information optical technique of diagnostics of the structure of polycrystalline films of blood plasma is proposed. The model of Mueller-matrix description of mechanisms of optical anisotropy of such objects as optical activity, birefringence, as well as linear and circular dichroism is suggested. The ensemble of informationally topical azimuthally stable Mueller-matrix invariants is determined. Within the statistical analysis of such parameters distributions the objective criteria of differentiation of films of blood plasma taken from healthy women and breast cancer patients were determined. From the point of view of probative medicine the operational characteristics (sensitivity, specificity and accuracy) of the information-optical method of Mueller-matrix mapping of polycrystalline films of blood plasma were found and its efficiency in diagnostics of breast cancer was demonstrated. Considered the prospects of applying the method in experimental medicine for differentiation of tissues of internal organs of healthy and diabetic rats.
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Yu. A. Ushenko, M. I. Sidor, M. V. Gritsyuk, G. D. Koval, O. Yu. Novakovskaya, "Laser system of the autofluorescence polarimetry of cytological layers at an early stage of cancer detection", Proc. SPIE 9166, Biosensing and Nanomedicine VII, 916617 (27 August 2014); doi: 10.1117/12.2061173; https://doi.org/10.1117/12.2061173
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