19 November 2014 Nanoparticle-assisted STED, theory, and experimental demonstration (presentation video)
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Abstract
We show that metal nanoparticles can be used to improve the performance of super-resolution fluorescence nanoscopes based on stimulated-emission-depletion (STED). Compared with a standard STED nanoscope, we show theoretically a resolution improvement by more than an order of magnitude, or equivalently, depletion intensity reductions by more than 2 orders of magnitude and an even stronger photostabilization. Moreover, we present experimental evidence that an optimum resolution, limited by the sizes of the particles used, can be reached for the hybrid NPs for a power of the STED beam one order of magnitude smaller than for the bare cores.
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Yannick Sonnefraud, Yonatan Sivan, Hugo G. Sinclair, Christopher W. Dunsby, Mark A. Neil, Paul M. French, Stefan A. Maier, "Nanoparticle-assisted STED, theory, and experimental demonstration (presentation video)", Proc. SPIE 9169, Nanoimaging and Nanospectroscopy II, 916903 (19 November 2014); doi: 10.1117/12.2060993; https://doi.org/10.1117/12.2060993
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