Direct electronic probing of biological complexes formation

Eleonora Macchia; Maria Magliulo; Kyriaki Manoli; Francesco Giordano; Gerardo Palazzo; Luisa Torsi

doi:10.1117/12.2067934

3 October 2014 Direct electronic probing of biological complexes formation

Eleonora Macchia, Maria Magliulo, Kyriaki Manoli, Francesco Giordano, Gerardo Palazzo, Luisa Torsi

Proceedings Volume 9183, Organic Light Emitting Materials and Devices XVIII; 918302 (2014) https://doi.org/10.1117/12.2067934
Event: SPIE Organic Photonics + Electronics, 2014, San Diego, California, United States

Abstract

Functional bio-interlayer organic field - effect transistors (FBI-OFET), embedding streptavidin, avidin and neutravidin as bio-recognition element, have been studied to probe the electronic properties of protein complexes. The threshold voltage control has been achieved modifying the SiO₂ gate diaelectric surface by means of the deposition of an interlayer of bio-recognition elements. A threshold voltage shift with respect to the unmodified dielectric surface toward more negative potential values has been found for the three different proteins, in agreement with their isoelectric points. The relative responses in terms of source – drain current, mobility and threshold voltage upon exposure to biotin of the FBI-OFET devices have been compared for the three bio-recognition elements.

Citation Download Citation

Eleonora Macchia, Maria Magliulo, Kyriaki Manoli, Francesco Giordano, Gerardo Palazzo, and Luisa Torsi "Direct electronic probing of biological complexes formation", Proc. SPIE 9183, Organic Light Emitting Materials and Devices XVIII, 918302 (3 October 2014); https://doi.org/10.1117/12.2067934

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