3 October 2014 Direct electronic probing of biological complexes formation
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Abstract
Functional bio-interlayer organic field - effect transistors (FBI-OFET), embedding streptavidin, avidin and neutravidin as bio-recognition element, have been studied to probe the electronic properties of protein complexes. The threshold voltage control has been achieved modifying the SiO2 gate diaelectric surface by means of the deposition of an interlayer of bio-recognition elements. A threshold voltage shift with respect to the unmodified dielectric surface toward more negative potential values has been found for the three different proteins, in agreement with their isoelectric points. The relative responses in terms of source – drain current, mobility and threshold voltage upon exposure to biotin of the FBI-OFET devices have been compared for the three bio-recognition elements.
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Eleonora Macchia, Eleonora Macchia, Maria Magliulo, Maria Magliulo, Kyriaki Manoli, Kyriaki Manoli, Francesco Giordano, Francesco Giordano, Gerardo Palazzo, Gerardo Palazzo, Luisa Torsi, Luisa Torsi, } "Direct electronic probing of biological complexes formation", Proc. SPIE 9183, Organic Light Emitting Materials and Devices XVIII, 918302 (3 October 2014); doi: 10.1117/12.2067934; https://doi.org/10.1117/12.2067934
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