20 October 2014 Molecular imaging in the College of Optical Sciences: an overview of two decades of instrumentation development
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During the past two decades, researchers at the University of Arizona’s Center for Gamma-Ray Imaging (CGRI) have explored a variety of approaches to gamma-ray detection, including scintillation cameras, solid-state detectors, and hybrids such as the intensified Quantum Imaging Device (iQID) configuration where a scintillator is followed by optical gain and a fast CCD or CMOS camera. We have combined these detectors with a variety of collimation schemes, including single and multiple pinholes, parallel-hole collimators, synthetic apertures, and anamorphic crossed slits, to build a large number of preclinical molecular-imaging systems that perform Single-Photon Emission Computed Tomography (SPECT), Positron Emission Tomography (PET), and X-Ray Computed Tomography (CT). In this paper, we discuss the themes and methods we have developed over the years to record and fully use the information content carried by every detected gamma-ray photon.
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Lars R. Furenlid, Lars R. Furenlid, Harrison H. Barrett, Harrison H. Barrett, H. Bradford Barber, H. Bradford Barber, Eric W. Clarkson, Eric W. Clarkson, Matthew A. Kupinski, Matthew A. Kupinski, Zhonglin Liu, Zhonglin Liu, Gail D. Stevenson, Gail D. Stevenson, James M. Woolfenden, James M. Woolfenden, "Molecular imaging in the College of Optical Sciences: an overview of two decades of instrumentation development", Proc. SPIE 9186, Fifty Years of Optical Sciences at The University of Arizona, 91860J (20 October 2014); doi: 10.1117/12.2064808; https://doi.org/10.1117/12.2064808


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