5 September 2014 Combined Raman spectroscopy and autofluoresence imaging method for in vivo skin tumor diagnosis
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Abstract
The fluorescence and Raman spectroscopy (RS) combined method of in vivo detection of malignant human skin cancer was demonstrated. The fluorescence analysis was used for detection of abnormalities during fast scanning of large tissue areas. In suspected cases of malignancy the Raman spectrum analysis of biological tissue was performed to determine the type of neoplasm. A special RS phase method was proposed for in vivo identification of skin tumor. Quadratic Discriminant Analysis was used for tumor type classification on phase planes. It was shown that the application of phase method provides a diagnosis of malignant melanoma with a sensitivity of 89% and a specificity of 87%.
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V. P. Zakharov, V. P. Zakharov, I. A. Bratchenko, I. A. Bratchenko, O. O. Myakinin, O. O. Myakinin, D. N. Artemyev, D. N. Artemyev, Y. A. Khristoforova, Y. A. Khristoforova, S. V. Kozlov, S. V. Kozlov, A. A. Moryatov, A. A. Moryatov, } "Combined Raman spectroscopy and autofluoresence imaging method for in vivo skin tumor diagnosis", Proc. SPIE 9198, Ultrafast Nonlinear Imaging and Spectroscopy II, 919804 (5 September 2014); doi: 10.1117/12.2061667; https://doi.org/10.1117/12.2061667
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