The use of tunable lasers for isotope separation and selective photochemical reactions is a field or rapidly growing research. Many economic and scientific benefits of this research can be identified. A number of basic methods of laser isotope separation have been successful. Examples of each are compared and the laser requirements discussed. The advantages of using lasers to enrich various isotopes or to separate the elements using photochemistry are described. The uses of lasers and specific laser wavelengths are outlined.