11 September 2014 Evaluation of neural cochlear structures after noise trauma using x-ray tomography
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Abstract
According to the World Health Organization (WHO), in 2010 hearing loss affected more than 278 million people worldwide. The loss of hearing and communication has significant consequences on the emotional well-being of each affected individual. The estimated socio-economic impact is about $100 billion in unrealized household income per year. Despite this impact on society, no Food and Drug Administration (FDA) approved drug intervention is available today that would either protect or reverse the effects of hearing loss. A limiting factor for all efforts to validate drugs for treatment relates to the time consuming animal experiments and subsequent histology. Here, we present an imaging method that is superior to current gold standard methods in flexibility and time for evaluation of histology. Tissue processing times are reduced from weeks to hours. As an example, we show that Brain Derived Neurotrophic Factor (BDNF) reduces the effect of noise induced hearing loss.
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Claus-Peter Richter, Whitney Liddy, Amanda Vo, Hunter Young, Stuart Stock, Xianghui Xiao, Donna Whitlon, "Evaluation of neural cochlear structures after noise trauma using x-ray tomography", Proc. SPIE 9212, Developments in X-Ray Tomography IX, 92120U (11 September 2014); doi: 10.1117/12.2062385; https://doi.org/10.1117/12.2062385
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