17 September 2014 Adaptive SPECT imaging with crossed-slit apertures
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Preclinical single-photon emission computed tomography (SPECT) is an essential tool for studying the pro-gression, response to treatment, and physiological changes in small animal models of human disease. The wide range of imaging applications is often limited by the static design of many preclinical SPECT systems. We have developed a prototype imaging system that replaces the standard static pinhole aperture with two sets of movable, keel-edged copper-tungsten blades configured as crossed (skewed) slits. These apertures can be positioned independently between the object and detector, producing a continuum of imaging configurations in which the axial and transaxial magnifications are not constrained to be equal. We incorporated a megapixel silicon double-sided strip detector to permit ultrahigh-resolution imaging. We describe the configuration of the adjustable slit aperture imaging system and discuss its application toward adaptive imaging, and reconstruction techniques using an accurate imaging forward model, a novel geometric calibration technique, and a GPU-based ultra-high-resolution reconstruction code.
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Heather L. Durko, Heather L. Durko, Lars R. Furenlid, Lars R. Furenlid, "Adaptive SPECT imaging with crossed-slit apertures", Proc. SPIE 9214, Medical Applications of Radiation Detectors IV, 92140E (17 September 2014); doi: 10.1117/12.2066188; https://doi.org/10.1117/12.2066188

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