Spectral imaging of breast fibroadenoma using second-harmonic generation

Liqin Zheng; Yuhua Wang

doi:10.1117/12.2068893

17 September 2014 Spectral imaging of breast fibroadenoma using second-harmonic generation

Liqin Zheng, Yuhua Wang

Proceedings Volume 9230, Twelfth International Conference on Photonics and Imaging in Biology and Medicine (PIBM 2014); 92300K (2014) https://doi.org/10.1117/12.2068893
Event: Twelfth International Conference on Photonics and Imaging in Biology and Medicine (PIBM 2014), 2014, Wuhan, China

Abstract

Fibroadenoma (FA), typically composed of stroma and epithelial cells, is a very common benign breast disease. Women with FA are associated with an increased risk of future breast cancer. The objective of this study was to demonstrate the potential of multiphoton laser scanning microscopy (MPLSM) for characterizing the morphology of collagen in the human breast fibroadenomas. In the study, high-contrast SHG images of human normal breast tissues and fibroadenoma tissues were obtained for comparison. The morphology of collagen was different between normal breast tissue and fibroadenoma. This study shows that MPLSM has the ability to distinguish fibroadenoma tissues from the normal breast tissues based on the noninvasive SHG imaging. With the advent of the clinical portability of miniature MPLSM, we believe that the technique has great potential to be used in vivo studies and for monitoring the treatment responses of fibroadenomas in clinical.

Citation Download Citation

Liqin Zheng and Yuhua Wang "Spectral imaging of breast fibroadenoma using second-harmonic generation", Proc. SPIE 9230, Twelfth International Conference on Photonics and Imaging in Biology and Medicine (PIBM 2014), 92300K (17 September 2014); https://doi.org/10.1117/12.2068893

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KEYWORDS

Tissues

Breast

Collagen

Second-harmonic generation

Breast cancer

Microscopy

Multiphoton microscopy

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