Preliminary study on novel targeted anti-tumor drug aminoglucose based-doxorubicin

Siwen Li; Chang Liu; Yue-qing Gu

doi:10.1117/12.2068712

17 September 2014 Preliminary study on novel targeted anti-tumor drug aminoglucose based-doxorubicin

Siwen Li, Chang Liu, Yue-qing Gu

Proceedings Volume 9230, Twelfth International Conference on Photonics and Imaging in Biology and Medicine (PIBM 2014); 923019 (2014) https://doi.org/10.1117/12.2068712
Event: Twelfth International Conference on Photonics and Imaging in Biology and Medicine (PIBM 2014), 2014, Wuhan, China

Abstract

In order to improve Doxorubicin (Dox) targeting in vivo and reduce toxicity, use the targeting ligand 2-deoxy-aminoglucose (2DG) to modify Doxorubicin to form a new anti-tumor drug. The products was charactered by ¹H-NMR, MS, and the targeting research by near-infrared imaging. Compared with Dox , the product treating MCF-7 and U87MG cells shows higher antitumor activity in vitro by MTT assay. In conclusion, the modified product effectively enhance the targeting and pharmacodynamics in contrast with Dox, and it would be a potential therapeutic drug for cancer.

Citation Download Citation

Siwen Li, Chang Liu, and Yue-qing Gu "Preliminary study on novel targeted anti-tumor drug aminoglucose based-doxorubicin", Proc. SPIE 9230, Twelfth International Conference on Photonics and Imaging in Biology and Medicine (PIBM 2014), 923019 (17 September 2014); https://doi.org/10.1117/12.2068712

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