Research of second harmonic generation images based on texture analysis

Yao Liu; Yan Li; Haiming Gong; Xiaoqin Zhu; Zufang Huang; Guannan Chen

doi:10.1117/12.2068380

17 September 2014 Research of second harmonic generation images based on texture analysis

Yao Liu, Yan Li, Haiming Gong, Xiaoqin Zhu, Zufang Huang, Guannan Chen

Proceedings Volume 9230, Twelfth International Conference on Photonics and Imaging in Biology and Medicine (PIBM 2014); 92301J (2014) https://doi.org/10.1117/12.2068380
Event: Twelfth International Conference on Photonics and Imaging in Biology and Medicine (PIBM 2014), 2014, Wuhan, China

Abstract

Texture analysis plays a crucial role in identifying objects or regions of interest in an image. It has been applied to a variety of medical image processing, ranging from the detection of disease and the segmentation of specific anatomical structures, to differentiation between healthy and pathological tissues. Second harmonic generation (SHG) microscopy as a potential noninvasive tool for imaging biological tissues has been widely used in medicine, with reduced phototoxicity and photobleaching. In this paper, we clarified the principles of texture analysis including statistical, transform, structural and model-based methods and gave examples of its applications, reviewing studies of the technique. Moreover, we tried to apply texture analysis to the SHG images for the differentiation of human skin scar tissues. Texture analysis method based on local binary pattern (LBP) and wavelet transform was used to extract texture features of SHG images from collagen in normal and abnormal scars, and then the scar SHG images were classified into normal or abnormal ones. Compared with other texture analysis methods with respect to the receiver operating characteristic analysis, LBP combined with wavelet transform was demonstrated to achieve higher accuracy. It can provide a new way for clinical diagnosis of scar types. At last, future development of texture analysis in SHG images were discussed.

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Yao Liu, Yan Li, Haiming Gong, Xiaoqin Zhu, Zufang Huang, and Guannan Chen "Research of second harmonic generation images based on texture analysis", Proc. SPIE 9230, Twelfth International Conference on Photonics and Imaging in Biology and Medicine (PIBM 2014), 92301J (17 September 2014); https://doi.org/10.1117/12.2068380

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KEYWORDS

Second-harmonic generation

Wavelet transforms

Analytical research

Statistical analysis

Tissues

Image segmentation

Harmonic generation

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