A fast and high-sensitive dual-wavelength diffuse optical tomography system using digital lock-in photon-counting technique

Weiting Chen; Xi Yi; Huijuan Zhao; Feng Gao

doi:10.1117/12.2068381

17 September 2014 A fast and high-sensitive dual-wavelength diffuse optical tomography system using digital lock-in photon-counting technique

Weiting Chen, Xi Yi, Huijuan Zhao, Feng Gao

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Proceedings Volume 9230, Twelfth International Conference on Photonics and Imaging in Biology and Medicine (PIBM 2014); 92301K (2014) https://doi.org/10.1117/12.2068381
Event: Twelfth International Conference on Photonics and Imaging in Biology and Medicine (PIBM 2014), 2014, Wuhan, China

Abstract

We presented a novel dual-wavelength diffuse optical imaging system which can perform 2-D or 3-D imaging fast and high-sensitively for monitoring the dynamic change of optical parameters. A newly proposed lock-in photon-counting detection method was adopted for week optical signal collection, which brought in excellent property as well as simplified geometry. Fundamental principles of the lock-in photon-counting detection were elaborately demonstrated, and the feasibility was strictly verified by the linearity experiment. Systemic performance of the prototype set up was experimentally accessed, including stray light rejection and inherent interference. Results showed that the system possessed superior anti-interference capability (under 0.58% in darkroom) compared with traditional photon-counting detection, and the crosstalk between two wavelengths was lower than 2.28%. For comprehensive assessment, 2-D phantom experiments towards relatively large dimension model (diameter of 4cm) were conducted. Different absorption targets were imaged to investigate detection sensitivity. Reconstruction image under all conditions was exciting, with a desirable SNR. Study on image quality v.s. integration time put forward a new method for accessing higher SNR with the sacrifice of measuring speed. In summary, the newly developed system showed great potential in promoting detection sensitivity as well as measuring speed. This will make substantial progress in dynamically tracking the blood concentration distribution in many clinical areas, such as small animal disease modeling, human brain activity research and thick tissues (for example, breast) diagnosis.

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Weiting Chen, Xi Yi, Huijuan Zhao, and Feng Gao "A fast and high-sensitive dual-wavelength diffuse optical tomography system using digital lock-in photon-counting technique", Proc. SPIE 9230, Twelfth International Conference on Photonics and Imaging in Biology and Medicine (PIBM 2014), 92301K (17 September 2014); https://doi.org/10.1117/12.2068381

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KEYWORDS

Modulation

Imaging systems

Absorption

Demodulation

Diffuse optical tomography

Photodetectors

Signal detection

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