17 September 2014 Differentiating fibroadenoma and ductal carcinoma in situ from normal breast tissue by multiphoton microscopy
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Proceedings Volume 9230, Twelfth International Conference on Photonics and Imaging in Biology and Medicine (PIBM 2014); 92301N (2014) https://doi.org/10.1117/12.2068512
Event: Twelfth International Conference on Photonics and Imaging in Biology and Medicine (PIBM 2014), 2014, Wuhan, China
Abstract
Fibroadenoma (FA) is the most common benign tumor of the female breast and several studies have reported that women with it have increased risk of breast cancer. While the ductal carcinoma in situ (DCIS) is a very early form of breast cancer. Thus, early detections of FA and DCIS are critical for improving breast tumor outcome and survival. In this paper, we use multiphoton microscopy (MPM) to obtain the high-contrast images of fresh, unfixed, unstained human breast specimens (normal breast tissue, FA and DCIS). Our results show that MPM has the ability to identify the characteristics of FA and DCIS including changes of duct architecture and collagen morphology. These results are consistent with the histological results. With the advancement of MPM, the technique has potential ability to serve as a real-time noninvasive imaging tool for early detection of breast tumor.
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Yuting Nie, Yuting Nie, Yan Wu, Yan Wu, Yuane Lian, Yuane Lian, Fangmeng Fu, Fangmeng Fu, Chuan Wang, Chuan Wang, Jianxin Chen, Jianxin Chen, } "Differentiating fibroadenoma and ductal carcinoma in situ from normal breast tissue by multiphoton microscopy", Proc. SPIE 9230, Twelfth International Conference on Photonics and Imaging in Biology and Medicine (PIBM 2014), 92301N (17 September 2014); doi: 10.1117/12.2068512; https://doi.org/10.1117/12.2068512
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