You have requested a machine translation of selected content from our databases. This functionality is provided solely for your convenience and is in no way intended to replace human translation. Neither SPIE nor the owners and publishers of the content make, and they explicitly disclaim, any express or implied representations or warranties of any kind, including, without limitation, representations and warranties as to the functionality of the translation feature or the accuracy or completeness of the translations.
Translations are not retained in our system. Your use of this feature and the translations is subject to all use restrictions contained in the Terms and Conditions of Use of the SPIE website.
18 November 2014Synthesis of folate receptor-targeted photosensitizers for photodynamic therapy
A series of amphiphilic benzylidene cycloalkanes ketone photosensitizers C1-C4 with or without folate receptor-targeted
agent were designed and synthesized. Their photophysical properties and in vitro photodynamic therapy (PDT) effects
were studied. The results showed that all compounds exhibited appropriate lipid-water partition coefficients and high
reactive oxygen yields. The introduction of the folate receptor-targeted agent had no obvious influence on the basic
photophysical & photochemical properties of C2 and C4 compared to those of their corresponding prototype compounds
(C1 and C3). In vitro studies were carried out using MCF-7 cells (FR+), Hela cells (FR+) and A549 cells (FR-), which
represented different levels of folate receptor (FR) expression. All of C1-C4 showed low dark toxicity and superior PDT
effects compared with the clinical drug PSD-007 (a mixture of porphyrins). What’s more, folate receptor-targeted
photosensitizers (C2 and C4) achieved higher accumulation and more excellent PDT effects in MCF-7 cells (FR+) and
Hela cells (FR+) than photosensitizers (C1 and C3) without folate receptor-targeted agent and PSD-007. The photocytotoxicity
of these photosensitizers showed no obvious differences in A549 cells (FR-).
The alert did not successfully save. Please try again later.
Yanyan Fang, Xiaopu Wang, Qianli Zou, Yuxia Zhao, Feipeng Wu, "Synthesis of folate receptor-targeted photosensitizers for photodynamic therapy," Proc. SPIE 9268, Optics in Health Care and Biomedical Optics VI, 92680O (18 November 2014);