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18 November 2014 Vessel constriction correlated with local singlet oxygen generation during vascular targeted photodynamic therapy
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Abstract
In this study, the vessel constriction was measured as a biological indicator of acute vascular response after vascular targeted photodynamic therapy (V-PDT). During V-PDT treatment, the near-infrared (NIR) singlet oxygen (1O2) luminescence at 1270 nm generated in blood vessels in a dorsal skinfold window chamber model in vivo was directly monitored using a custom built high-sensitive NIR imaging system. In order to compare the acute vascular response, various irradiances with the same light dose were utilized for treatments. The obtained results show that the complete arteriole constriction occurred frequently, while some of the larger veins were constricted partially. For the vessels that have significant constriction after V-PDT, our preliminary data suggest that the vasoconstriction in the selected ROIs are roughly correlated with the local cumulative 1O2 luminescence intensities. This study implies that the 1O2 luminescence dosimetry maybe also effective for evaluating V-PDT efficiency.
© (2014) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
Lisheng Lin, Yirong Li, Jinde Zhang, Zou Tan, Defu Chen, Shusen Xie, Ying Gu, and Buhong Li "Vessel constriction correlated with local singlet oxygen generation during vascular targeted photodynamic therapy", Proc. SPIE 9268, Optics in Health Care and Biomedical Optics VI, 92680T (18 November 2014); https://doi.org/10.1117/12.2074038
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