Wide field-of-view microscopy using compressive sensing

Jie Wang; Jigang Wu

doi:10.1117/12.2071601

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18 November 2014 Wide field-of-view microscopy using compressive sensing

Proceedings Volume 9268, Optics in Health Care and Biomedical Optics VI; 926811 (2014) https://doi.org/10.1117/12.2071601
Event: SPIE/COS Photonics Asia, 2014, Beijing, China

Abstract

Focus-grid-based wide field-of-view microscope has been developed to break the trade-off of resolution and field of view in conventional microscopy. In the wide field-of-view microscopy, the whole sample area has to be scanned with at least Nyquist-frequency sampling for image reconstruction. We propose a novel scanning mechanism using compressive sensing (CS), where the scanning of focal spots covers only a portion of the sample. Our preliminary studies show that 75% of scanning area is enough to reconstruct a decent image. Thus we can reduce the acquisition data which allow for simpler scanning mechanism and data acquisition.

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Jie Wang and Jigang Wu "Wide field-of-view microscopy using compressive sensing", Proc. SPIE 9268, Optics in Health Care and Biomedical Optics VI, 926811 (18 November 2014); https://doi.org/10.1117/12.2071601

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