20 November 2014 Precise 13CO2/12CO2 isotopic ratio measurements for breath diagnosis with a 2-μm diode laser
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Abstract
A laser spectrometer based on a distributed-feedback semiconductor diode laser at 2 μm is developed to measure the changes of 13CO2/12CO2 isotope ratio in exhaled breath sample with the CO2 concentration of ~4%. It is characterized by a simplified optical layout, in which a single detector and associated electronics are used to probe CO2 spectrum. The cell has 10 cm long base length with 26.4 m optical path length in total and 330 cm3 volume. The cell pressure and temperature are controlled at 50 Torr and 28℃, respectively. The best 13δ precision of 0.06‰ was achieved by using wavelet denoising and Kalman filter.
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Mingguo Sun, Hongliang Ma, Zhensong Cao, Kun Liu, Guishi Wang, Lei Wang, Qiang Liu, Xiaoming Gao, "Precise 13CO2/12CO2 isotopic ratio measurements for breath diagnosis with a 2-μm diode laser", Proc. SPIE 9268, Optics in Health Care and Biomedical Optics VI, 92681O (20 November 2014); doi: 10.1117/12.2071221; https://doi.org/10.1117/12.2071221
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