20 November 2014 Precise 13CO2/12CO2 isotopic ratio measurements for breath diagnosis with a 2-μm diode laser
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Abstract
A laser spectrometer based on a distributed-feedback semiconductor diode laser at 2 μm is developed to measure the changes of 13CO2/12CO2 isotope ratio in exhaled breath sample with the CO2 concentration of ~4%. It is characterized by a simplified optical layout, in which a single detector and associated electronics are used to probe CO2 spectrum. The cell has 10 cm long base length with 26.4 m optical path length in total and 330 cm3 volume. The cell pressure and temperature are controlled at 50 Torr and 28℃, respectively. The best 13δ precision of 0.06‰ was achieved by using wavelet denoising and Kalman filter.
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Mingguo Sun, Mingguo Sun, Hongliang Ma, Hongliang Ma, Zhensong Cao, Zhensong Cao, Kun Liu, Kun Liu, Guishi Wang, Guishi Wang, Lei Wang, Lei Wang, Qiang Liu, Qiang Liu, Xiaoming Gao, Xiaoming Gao, } "Precise 13CO2/12CO2 isotopic ratio measurements for breath diagnosis with a 2-μm diode laser", Proc. SPIE 9268, Optics in Health Care and Biomedical Optics VI, 92681O (20 November 2014); doi: 10.1117/12.2071221; https://doi.org/10.1117/12.2071221
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