Photoacoustic imaging of an inflammatory lesion model in the neonatal rat brain

Edgar Guevara; Romain Berti; Irène Londono; Ningshi Xie; Pierre Bellec; Frédéric Lesage; G. A. Lodygensky M.D.

doi:10.1117/12.2073720

25 September 2014 Photoacoustic imaging of an inflammatory lesion model in the neonatal rat brain

Edgar Guevara, Romain Berti, Irène Londono, Ningshi Xie, Pierre Bellec, Frédéric Lesage, G. A. Lodygensky M.D.

Proceedings Volume 9288, Photonics North 2014; 92880Q (2014) https://doi.org/10.1117/12.2073720
Event: Photonics North 2014, 2014, Montréal, Canada

Abstract

Periventricular leukomalacia (PVL) is a condition that may cause significant neurodevelopmental handicap in premature newborns. It is characterized by white matter injury, associated with inflammation. This work aimed to assess the impact of inflammation on cerebral oxygen saturation (sO₂) using depth-sensitive photoacoustic tomography (PAT). The aspects of PVL were reproduced in a rodent model by injection of lipopolysaccharide (LPS) into the corpus callosum. The results of this exploratory work reveal lower sO₂ values in LPS group, as compared to sham controls; showing decreased values in the corpus callosum and in the left cortex, ipsilateral to the injection site. Interhemispherical connectivity was not affected by LPS injection, as shown by functional connectivity analysis. This study supports the use of PAT as a non-invasive tool to assess oxygenation values in vivo in the newborn brain.

Citation Download Citation

Edgar Guevara, Romain Berti, Irène Londono, Ningshi Xie, Pierre Bellec, Frédéric Lesage, and G. A. Lodygensky M.D. "Photoacoustic imaging of an inflammatory lesion model in the neonatal rat brain", Proc. SPIE 9288, Photonics North 2014, 92880Q (25 September 2014); https://doi.org/10.1117/12.2073720

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available