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25 September 2014 Photoacoustic imaging of an inflammatory lesion model in the neonatal rat brain
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Proceedings Volume 9288, Photonics North 2014; 92880Q (2014)
Event: Photonics North 2014, 2014, Montréal, Canada
Periventricular leukomalacia (PVL) is a condition that may cause significant neurodevelopmental handicap in premature newborns. It is characterized by white matter injury, associated with inflammation. This work aimed to assess the impact of inflammation on cerebral oxygen saturation (sO2) using depth-sensitive photoacoustic tomography (PAT). The aspects of PVL were reproduced in a rodent model by injection of lipopolysaccharide (LPS) into the corpus callosum. The results of this exploratory work reveal lower sO2 values in LPS group, as compared to sham controls; showing decreased values in the corpus callosum and in the left cortex, ipsilateral to the injection site. Interhemispherical connectivity was not affected by LPS injection, as shown by functional connectivity analysis. This study supports the use of PAT as a non-invasive tool to assess oxygenation values in vivo in the newborn brain.
© (2014) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
Edgar Guevara, Romain Berti, Irène Londono, Ningshi Xie, Pierre Bellec, Frédéric Lesage, and G. A. Lodygensky M.D. "Photoacoustic imaging of an inflammatory lesion model in the neonatal rat brain", Proc. SPIE 9288, Photonics North 2014, 92880Q (25 September 2014);

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