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25 September 2014Photoacoustic imaging of an inflammatory lesion model in the neonatal rat brain
Edgar Guevara,1 Romain Berti,1,2 Irène Londono,3 Ningshi Xie,3 Pierre Bellec,3 Frédéric Lesagehttps://orcid.org/0000-0003-3699-1283,1,2 G. A. Lodygensky M.D.3
1Ecole Polytechnique de Montréal (Canada) 2Montreal Heart Institute (Canada) 3Univ. de Montréal (Canada)
Periventricular leukomalacia (PVL) is a condition that may cause significant neurodevelopmental handicap in premature newborns. It is characterized by white matter injury, associated with inflammation. This work aimed to assess the impact of inflammation on cerebral oxygen saturation (sO2) using depth-sensitive photoacoustic tomography (PAT). The aspects of PVL were reproduced in a rodent model by injection of lipopolysaccharide (LPS) into the corpus callosum. The results of this exploratory work reveal lower sO2 values in LPS group, as compared to sham controls; showing decreased values in the corpus callosum and in the left cortex, ipsilateral to the injection site. Interhemispherical connectivity was not affected by LPS injection, as shown by functional connectivity analysis. This study supports the use of PAT as a non-invasive tool to assess oxygenation values in vivo in the newborn brain.
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Edgar Guevara, Romain Berti, Irène Londono, Ningshi Xie, Pierre Bellec, Frédéric Lesage, G. A. Lodygensky M.D., "Photoacoustic imaging of an inflammatory lesion model in the neonatal rat brain," Proc. SPIE 9288, Photonics North 2014, 92880Q (25 September 2014); https://doi.org/10.1117/12.2073720