MRI-guided fiber-based fluorescence molecular tomography for preclinical atherosclerosis imaging

Baoqiang Li; Philippe Pouliot; Frederic Lesage

doi:10.1117/12.2074257

25 September 2014 MRI-guided fiber-based fluorescence molecular tomography for preclinical atherosclerosis imaging

Baoqiang Li, Philippe Pouliot, Frederic Lesage

Author Affiliations +

Proceedings Volume 9288, Photonics North 2014; 92880R (2014) https://doi.org/10.1117/12.2074257
Event: Photonics North 2014, 2014, Montréal, Canada

Abstract

Multi-modal imaging combining fluorescent molecular tomography (FMT) with MRI could provide information in these two modalities as well as optimize the recovery of functional information with MR-guidance. Here, we present a MRI-guided FMT system. An optical probe was designed consisting of a fiber plate on the top and bottom sides of the animal bed, respectively. In experiment, animal was installed between the two plates. Mounting fibers on each plate, transmission measuring could be conducted from both sides of the animal. Moreover, an accurate fluorescence reconstruction was achieved with MRI-derived anatomical guidance. The sensitivity of the FMT system was evaluated with a phantom showing that with long fibers, it was sufficient to detect 10nM Cy5.5 solution with ~28.5 dB in the phantom. The system was eventually used to image MMP activity involved in atherosclerosis with two ATX mice and two control mice. The reconstruction results were in agreement with ex vivo measurement.

Citation Download Citation

Baoqiang Li, Baoqiang Li, Philippe Pouliot, Philippe Pouliot, Frederic Lesage, Frederic Lesage, "MRI-guided fiber-based fluorescence molecular tomography for preclinical atherosclerosis imaging", Proc. SPIE 9288, Photonics North 2014, 92880R (25 September 2014); doi: 10.1117/12.2074257; https://doi.org/10.1117/12.2074257

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