Optical design of an optical coherence tomography and multispectral fluorescence imaging endoscope to detect early stage ovarian cancer

Tyler Tate; Molly Keenan; Elizabeth Swan; John Black; Urs Utzinger; Jennifer Barton

doi:10.1117/12.2073824

17 December 2014 Optical design of an optical coherence tomography and multispectral fluorescence imaging endoscope to detect early stage ovarian cancer

Tyler Tate, Molly Keenan, Elizabeth Swan, John Black, Urs Utzinger, Jennifer Barton

Author Affiliations +

Proceedings Volume 9293, International Optical Design Conference 2014; 92931F (2014) https://doi.org/10.1117/12.2073824
Event: International Optical Design Conference, 2014, Kohala Coast, Hawaii, United States

Abstract

The five year survival rate for ovarian cancer is over 90% if early detection occurs, yet no effective early screening method exists. We have designed and are constructing a dual modality Optical Coherence Tomography (OCT) and Multispectral Fluorescence Imaging (MFI) endoscope to optically screen the Fallopian tube and ovary for early stage cancer. The endoscope reaches the ovary via the natural pathway of the vagina, cervix, uterus and Fallopian tube. In order to navigate the Fallopian tube the endoscope must have an outer diameter of 600 μm, be highly flexible, steerable, tracking and nonperforating. The imaging systems consists of six optical subsystems, two from OCT and four from MFI. The optical subsystems have independent and interrelated design criteria. The endoscope will be tested on realistic tissue models and ex vivo tissue to prove feasibility of future human trials. Ultimately the project aims to provide women the first effective ovarian cancer screening technique.

Citation Download Citation

Tyler Tate, Molly Keenan, Elizabeth Swan, John Black, Urs Utzinger, and Jennifer Barton "Optical design of an optical coherence tomography and multispectral fluorescence imaging endoscope to detect early stage ovarian cancer", Proc. SPIE 9293, International Optical Design Conference 2014, 92931F (17 December 2014); https://doi.org/10.1117/12.2073824

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