26 February 2015 Preferential alignment of birefringent tissue measured with polarization sensitive techniques
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Assessing collagen alignment is of interest when evaluating a therapeutic strategy and evaluating its outcome in scar management. In this work we introduce a theoretical and experimental methodology for the quantification of collagen and birefringent media alignment based on polarized light transport. The technique relies on the fact that these materials exhibit directional anisotropy. A polarized Monte Carlo model and a spectro-polarimetric imaging system were devised to predict and measure the impact of birefringence on an impinging polarized light beam. Experiments conducted on birefringent phantoms, and biological samples consisting of highly packed parallel birefringent fibers, showed a good agreement with the analytical results.
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J. C. Ramella-Roman, J. C. Ramella-Roman, T. Ruiz, T. Ruiz, P. Ghassemi, P. Ghassemi, T. E. Travis, T. E. Travis, J. W. Shupp, J. W. Shupp, J. Chue-Sang, J. Chue-Sang, Y. Bai, Y. Bai, "Preferential alignment of birefringent tissue measured with polarization sensitive techniques", Proc. SPIE 9303, Photonic Therapeutics and Diagnostics XI, 93030I (26 February 2015); doi: 10.1117/12.2081338; https://doi.org/10.1117/12.2081338

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