26 February 2015 Two dimensional vibrations of the guinea pig apex organ of Corti measured in vivo using phase sensitive Fourier domain optical coherence tomography
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Abstract
In this study, we measure the in vivo apical-turn vibrations of the guinea pig organ of Corti in both axial and radial directions using phase-sensitive Fourier domain optical coherence tomography. The apical turn in guinea pig cochlea has best frequencies around 100 – 500 Hz which are relevant for human speech. Prior measurements of vibrations in the guinea pig apex involved opening the otic capsule, which has been questioned on the basis of the resulting changes to cochlear hydrodynamics. Here this limitation is overcome by measuring the vibrations through bone without opening the otic capsule. Furthermore, we have significantly reduced the surgery needed to access the guinea pig apex in the axial direction by introducing a miniature mirror inside the bulla. The method and preliminary data are discussed in this article.
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Sripriya Ramamoorthy, Yuan Zhang, Tracy Petrie, Anders Fridberger, Tianying Ren, Ruikang Wang, Steven L. Jacques, Alfred L. Nuttall, "Two dimensional vibrations of the guinea pig apex organ of Corti measured in vivo using phase sensitive Fourier domain optical coherence tomography", Proc. SPIE 9303, Photonic Therapeutics and Diagnostics XI, 93031L (26 February 2015); doi: 10.1117/12.2079673; https://doi.org/10.1117/12.2079673
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