26 February 2015 Optical diagnosis of mammary ductal carcinoma using advanced optical technology
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Clinical imaging techniques for diagnosing breast cancer mainly include X-ray mammography, ultrasound, and magnetic resonance imaging (MRI), which have respective drawbacks. Multiphoton microscopy (MPM) has become a potentially attractive optical technique to bridge the current gap in clinical utility. In this paper, MPM was used to image normal and ductal cancerous breast tissues, based on two-photon excited fluorescence (TPEF) and second harmonic generation (SHG). Our results showed that MPM has the ability to exhibit the microstructure of normal breast tissue, ductal carcinoma in situ (DCIS) and invasive ductal carcinoma (IDC) lesions at the molecular level comparable to histopathology. These findings indicate that, with integration of MPM into currently accepted clinical imaging system, it has the potential to make a real-time histological diagnosis of mammary ductal carcinoma in vivo.
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Yan Wu, Fangmeng Fu, Yuane Lian, Yuting Nie, Shuangmu Zhuo, Chuan Wang, and Jianxin Chen "Optical diagnosis of mammary ductal carcinoma using advanced optical technology", Proc. SPIE 9303, Photonic Therapeutics and Diagnostics XI, 93032P (26 February 2015); doi: 10.1117/12.2078066; https://doi.org/10.1117/12.2078066

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