26 February 2015 An opto-electronic joint detection system based on DSP aiming at early cervical cancer screening
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Abstract
The cervical cancer screening at a pre-cancer stage is beneficial to reduce the mortality of women. An opto-electronic joint detection system based on DSP aiming at early cervical cancer screening is introduced in this paper. In this system, three electrodes alternately discharge to the cervical tissue and three light emitting diodes in different wavelengths alternately irradiate the cervical tissue. Then the relative optical reflectance and electrical voltage attenuation curve are obtained by optical and electrical detection, respectively. The system is based on DSP to attain the portable and cheap instrument. By adopting the relative reflectance and the voltage attenuation constant, the classification algorithm based on Support Vector Machine (SVM) discriminates abnormal cervical tissue from normal. We use particle swarm optimization to optimize the two key parameters of SVM, i.e. nuclear factor and cost factor. The clinical data were collected on 313 patients to build a clinical database of tissue responses under optical and electrical stimulations with the histopathologic examination as the gold standard. The classification result shows that the opto-electronic joint detection has higher total coincidence rate than separate optical detection or separate electrical detection. The sensitivity, specificity, and total coincidence rate increase with the increasing of sample numbers in the training set. The average total coincidence rate of the system can reach 85.1% compared with the histopathologic examination.
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Weiya Wang, Mengyu Jia, Feng Gao, Lihong Yang, Pengpeng Qu, Changping Zou, Pengxi Liu, Huijuan Zhao, "An opto-electronic joint detection system based on DSP aiming at early cervical cancer screening", Proc. SPIE 9303, Photonic Therapeutics and Diagnostics XI, 93032W (26 February 2015); doi: 10.1117/12.2076587; https://doi.org/10.1117/12.2076587
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