26 February 2015 Ideal flushing agents for integrated optical acoustic imaging systems
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An increased number of integrated optical acoustic intravascular imaging systems have been researched and hold great hope for accurate diagnosing of vulnerable plaques and for guiding atherosclerosis treatment. However, in any intravascular environment, vascular lumen is filled with blood, which is a high-scattering source for optical and high frequency ultrasound signals. Blood must be flushed away to make images clear. To our knowledge, no research has been performed to find the ideal flushing agent that works for both optical and acoustic imaging techniques. We selected three solutions, mannitol, dextran and iohexol, as flushing agents because of their image-enhancing effects and low toxicities. Quantitative testing of these flushing agents was performed in a closed loop circulation model and in vivo on rabbits.
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Jiawen Li, Jiawen Li, Hataka Minami, Hataka Minami, Earl Steward, Earl Steward, Teng Ma, Teng Ma, Dilbahar Mohar, Dilbahar Mohar, Claire Robertson, Claire Robertson, K. Kirk Shung, K. Kirk Shung, Qifa Zhou, Qifa Zhou, Pranav M. Patel, Pranav M. Patel, Zhongping Chen, Zhongping Chen, "Ideal flushing agents for integrated optical acoustic imaging systems", Proc. SPIE 9303, Photonic Therapeutics and Diagnostics XI, 93032Z (26 February 2015); doi: 10.1117/12.2074696; https://doi.org/10.1117/12.2074696

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