Atherosclerotic plaque detection by confocal Brillouin and Raman microscopies

Zhaokai Meng; Berkay Basagaoglu; Vladislav V. Yakovlev

doi:10.1117/12.2080366

6 April 2015 Atherosclerotic plaque detection by confocal Brillouin and Raman microscopies

Zhaokai Meng, Berkay Basagaoglu, Vladislav V. Yakovlev

Proceedings Volume 9303, Photonic Therapeutics and Diagnostics XI; 93033N (2015) https://doi.org/10.1117/12.2080366
Event: SPIE BiOS, 2015, San Francisco, California, United States

Abstract

Atherosclerosis, the development of intraluminal plaque, is a fundamental pathology of cardiovascular system and remains the leading cause of morbidity and mortality worldwide. Biomechanical in nature, plaque rupture occurs when the mechanical properties of the plaque, related to the morphology and viscoelastic properties, are compromised, resulting in intraluminal thrombosis and reduction of coronary blood flow. In this report, we describe the first simultaneous application of confocal Brillouin and Raman microscopies to ex-vivo aortic wall samples. Such a non-invasive, high specific approach allows revealing a direct relationship between the biochemical and mechanical properties of atherosclerotic tissue.

Citation Download Citation

Zhaokai Meng, Berkay Basagaoglu, and Vladislav V. Yakovlev "Atherosclerotic plaque detection by confocal Brillouin and Raman microscopies", Proc. SPIE 9303, Photonic Therapeutics and Diagnostics XI, 93033N (6 April 2015); https://doi.org/10.1117/12.2080366

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