26 February 2015 Photoacoustic and ultrasound characterization of bone composition
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This study examines the sensitivity and specificity of backscattered ultrasound (US) and backscattering photoacoustic (PA) signals for bone composition variation assessment. The conventional approach in the evaluation of bone health relies on measurement of bone mineral density (BMD). Although, a crucial and probably the most important parameter, BMD is not the only factor defining the bone health. New trends in osteoporosis research, also pursue the changes in collagen content and cross-links with bone diseases and aging. Therefore, any non-invasive method that can assess any of these parameters can improve the diagnostic tools and also can help with the biomedical studies on the diseases themselves. Our previous studies show that both US and PA are responsive to changes in the BMD, PA is, in addition, sensitive to changes in the collagen content of the bone. Measurements were performed on bone samples before and after mild demineralization and decollagenization at the exact same points. Results show that combining both modalities can enhance the sensitivity and specificity of diagnostic tool.
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Bahman Lashkari, Bahman Lashkari, Lifeng Yang, Lifeng Yang, Lixian Liu, Lixian Liu, Joel W. Y. Tan, Joel W. Y. Tan, Andreas Mandelis, Andreas Mandelis, } "Photoacoustic and ultrasound characterization of bone composition", Proc. SPIE 9303, Photonic Therapeutics and Diagnostics XI, 93033X (26 February 2015); doi: 10.1117/12.2181093; https://doi.org/10.1117/12.2181093

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