2 March 2015 Simultaneous fingerprint and high-wavenumber Raman endoscopy for in vivo diagnosis of colorectal precancer
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Abstract
This work aims to apply a fiber-optic Raman spectroscopy technique for in vivo assessment of adenomatous polyps during clinical colonoscopy. We have developed a fiber-optic Raman endoscopic technique capable of simultaneously acquiring both the fingerprint (FP) (i.e., 800–1800 cm-1) and high-wavenumber (HW) (i.e., 2800–3600 cm-1) Raman spectra for real-time assessment of colorectal carcinogenesis. Simultaneous FP/HW Raman endoscopy provides a diagnostic sensitivity of 90.9% and specificity of 83.3% for differentiating adenoma from hyperplastic polyps, which is superior to either the FP or HW Raman technique alone. This study shows that simultaneous FP/HW Raman spectroscopy has the potential for improving early diagnosis of adenomatous polyps in vivo during colonoscopic examination.
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Kan Lin, Jianfeng Wang, Mads Sylvest Bergholt, Wei Zheng, Hongzhi Xu, Jian-lin Ren, Khek Yu Ho, Ming Teh, Khay Guan Yeoh, Zhiwei Huang, "Simultaneous fingerprint and high-wavenumber Raman endoscopy for in vivo diagnosis of colorectal precancer", Proc. SPIE 9304, Endoscopic Microscopy X; and Optical Techniques in Pulmonary Medicine II, 93040V (2 March 2015); doi: 10.1117/12.2080851; https://doi.org/10.1117/12.2080851
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