Efficacy of combined photothermal therapy and chemotherapeutic drugs

Steen J. Madsen; En-Chung Shih; Henry Hirschberg M.D.

doi:10.1117/12.2080354

10 March 2015 Efficacy of combined photothermal therapy and chemotherapeutic drugs

Steen J. Madsen, En-Chung Shih, Henry Hirschberg M.D.

Proceedings Volume 9305, Optical Techniques in Neurosurgery, Neurophotonics, and Optogenetics II; 93050E (2015) https://doi.org/10.1117/12.2080354
Event: SPIE BiOS, 2015, San Francisco, California, United States

Abstract

Hyperthermia has been shown to enhance the effects of chemotherapeutic agents in a wide variety of cancers. The purpose of this study was to investigate the combined effects of a number of commonly used chemotherapeutic drugs (bleomycin, doxorubicin and cisplatin) with photothermal therapy (PTT)-induced hyperthermia in an in vitro system consisting of human head and neck squamous carcinoma cells and murine lymphocytic monocytes which were used as delivery vehicles for gold-silica nanoshells (AuNS). PTT was accomplished via near infra-red (NIR) irradiation of AuNS. The results showed that PTT combined with cisplatin resulted in only a mild degree of synergism while additive effects were observed for concurrent treatments of PTT and doxorubicin and PTT and bleomycin.

Citation Download Citation

Steen J. Madsen, En-Chung Shih, and Henry Hirschberg M.D. "Efficacy of combined photothermal therapy and chemotherapeutic drugs", Proc. SPIE 9305, Optical Techniques in Neurosurgery, Neurophotonics, and Optogenetics II, 93050E (10 March 2015); https://doi.org/10.1117/12.2080354

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