10 March 2015 Real-time quantitative fluorescence imaging using a single snapshot optical properties technique for neurosurgical guidance
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Abstract
Fluorescence imaging has shown promise as an adjunct to improve the extent of resection in neurosurgery and oncologic surgery. Nevertheless, current fluorescence imaging techniques do not account for the heterogeneous attenuation effects of tissue optical properties. In this work, we present a novel imaging system that performs real time quantitative fluorescence imaging using Single Snapshot Optical Properties (SSOP) imaging. We developed the technique and performed initial phantom studies to validate the quantitative capabilities of the system for intraoperative feasibility. Overall, this work introduces a novel real-time quantitative fluorescence imaging method capable of being used intraoperatively for neurosurgical guidance.
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Pablo A. Valdes, Joseph Angelo, Sylvain Gioux, "Real-time quantitative fluorescence imaging using a single snapshot optical properties technique for neurosurgical guidance", Proc. SPIE 9305, Optical Techniques in Neurosurgery, Neurophotonics, and Optogenetics II, 93050J (10 March 2015); doi: 10.1117/12.2085051; https://doi.org/10.1117/12.2085051
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