4 March 2015 A novel broadband Raman endoscopy for in vivo diagnosis of intestinal metaplasia in the stomach
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Abstract
We report a novel simultaneous fingerprint (FP) and high-wavenumber (HW) fiber-optic Raman spectroscopy developed for in vivo diagnosis of intestinal metaplasia (IM) in the stomach under wide-field endoscopic imaging. The FP/HW Raman endoscopy technique was performed to differentiate IM from normal tissues with sensitivity of 89% and specificity of 83%. This study shows the great potential of the FP/HW Raman endoscopic technique for early diagnosis of non-neoplastic gastric disease in vivo during routine endoscopic examination.
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Kan Lin, Kan Lin, Mads Sylvest Bergholt, Mads Sylvest Bergholt, Jianfeng Wang, Jianfeng Wang, Wei Zheng, Wei Zheng, Hongzhi Xu, Hongzhi Xu, Jian-lin Ren, Jian-lin Ren, Khek Yu Ho, Khek Yu Ho, Ming Teh, Ming Teh, Khay Guan Yeoh, Khay Guan Yeoh, Zhiwei Huang, Zhiwei Huang, } "A novel broadband Raman endoscopy for in vivo diagnosis of intestinal metaplasia in the stomach", Proc. SPIE 9313, Advanced Biomedical and Clinical Diagnostic and Surgical Guidance Systems XIII, 93130I (4 March 2015); doi: 10.1117/12.2080896; https://doi.org/10.1117/12.2080896
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