Non-invasive diagnosis and continuous monitoring of thrombosis in clinics by near-infrared spectroscopy

Ting Li; Yunglong Sun; Xiao Chen; Yue Zhao; Rongrong Ren; Mushuang Liu

doi:10.1117/12.2081181

4 March 2015 Non-invasive diagnosis and continuous monitoring of thrombosis in clinics by near-infrared spectroscopy

Ting Li, Yunglong Sun, Xiao Chen, Yue Zhao, Rongrong Ren, Mushuang Liu

Proceedings Volume 9313, Advanced Biomedical and Clinical Diagnostic and Surgical Guidance Systems XIII; 931318 (2015) https://doi.org/10.1117/12.2081181
Event: SPIE BiOS, 2015, San Francisco, California, United States

Abstract

Thrombosis became one of the most severe disease hazard to human health, and it incidence rate grows increasingly higher throughout the world. The conventional diagnosis and monitoring thrombosis mainly relied on the invasive techniques, e.g., digital subtraction angiography and blood sample analysis, and expensive and ionizing techniques, e.g., magnetic resonance angiography. And those techniques can not measure continuously. Here we reported our preliminary exploration of using near-infrared spectroscopy (NIRS) in clinical monitoring of thrombosis. 7 healthy subjects and 6 thrombosis patients at similar age participated the NIRS measurements of oxy- and deoxy- hemoglobin ([HbO2] and [Hb]) on 6 particular parts of legs. We repeated [HbO2] measurement at the same specified time each day after thrombolytic therapy for one single-leg-DVT patient, and terminated till the patient was cured and left hospital. We found that：(1) [HbO2] kept lower in thrombosis patients and [Hb] kept lower in healthy people (p<0.001); (2) [HbO2] kept increasing in the thrombosis leg but decreasing in healthy leg for the patients after thrombolytic therapy, and coincidently, [HbO2] acted consistent just when the patients were cured and left. Our study successfully extended the application of NIRS in noninvasive, continuous, and low-cost monitoring of thrombosis in clinics. Our findings showed the powerful potential of [HbO2] by NIRS in diagnosis and therapeutic effect evaluation of thrombosis.

Citation Download Citation

Ting Li, Yunglong Sun, Xiao Chen, Yue Zhao, Rongrong Ren, and Mushuang Liu "Non-invasive diagnosis and continuous monitoring of thrombosis in clinics by near-infrared spectroscopy", Proc. SPIE 9313, Advanced Biomedical and Clinical Diagnostic and Surgical Guidance Systems XIII, 931318 (4 March 2015); https://doi.org/10.1117/12.2081181

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available