Systematic optimization of MRI guided near infrared diffuse optical spectroscopy in breast

Yan Zhao; Michael A. Mastanduno; Shudong Jiang; Fadi El-Ghussein; Junqing Xu; Jiang Gui; Brian W. Pogue; Keith D. Paulsen

doi:10.1117/12.2079453

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5 March 2015 Systematic optimization of MRI guided near infrared diffuse optical spectroscopy in breast

Yan Zhao, Michael A. Mastanduno, Shudong Jiang, Fadi El-Ghussein, Junqing Xu, Jiang Gui, Brian W. Pogue, Keith D. Paulsen

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Proceedings Volume 9316, Multimodal Biomedical Imaging X; 931605 (2015) https://doi.org/10.1117/12.2079453
Event: SPIE BiOS, 2015, San Francisco, California, United States

Abstract

A hybrid frequency domain (FD)-continuous wave (CW) MRI/NIRS system was validated in a clinical trial involving patients with at least ACR 4 radiologic findings in Xi’an, China. In this study, MRI guided nonlinear iterative reconstruction of near-infrared spectroscopy (NIRS) images with limited phase data is investigated. In addition, a systematic optimization of the system hardware design has been conducted as well. We are able to get less than 3% variation in tumor contrast to the surrounding normal tissue, by reducing the number of FD detectors from 16 to 6, showing the potential of reducing the FD detectors. Furthermore, a lookup table of the scattering properties has been made by averaging four MRI-identified breast density groups. By using this look-up table for the patient with the noisy phase data, similar AUCs and p-values are achieved for differentiating the malignant from benign patients.

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Yan Zhao, Michael A. Mastanduno, Shudong Jiang, Fadi El-Ghussein, Junqing Xu, Jiang Gui, Brian W. Pogue, and Keith D. Paulsen "Systematic optimization of MRI guided near infrared diffuse optical spectroscopy in breast", Proc. SPIE 9316, Multimodal Biomedical Imaging X, 931605 (5 March 2015); https://doi.org/10.1117/12.2079453

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