5 March 2015 Compact Raman needle probe with fine needle aspiration biopsy for solid tissues
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Raman spectroscopy represents a label-free vibrational spectroscopic technique for studying the biochemical and biomolecular compositions of human body. Raman probe is a key component to facilitate the in vivo diagnosis by using Raman spectroscopy. We investigated a compact Raman needle probe design to be integrated into a device that can also take biopsies of solid tissues for cytological assessment, enabling concurrent Raman spectroscopic interrogation and fine needle aspiration biopsy with a single needle penetration. We described the fabrication of the Raman needle probe and its assembly with the biopsy device. Example Raman spectra of various solid tissues are given.
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Jianfeng Wang, Jianfeng Wang, Wei Zheng, Wei Zheng, Zhiwei Huang, Zhiwei Huang, } "Compact Raman needle probe with fine needle aspiration biopsy for solid tissues", Proc. SPIE 9317, Optical Fibers and Sensors for Medical Diagnostics and Treatment Applications XV, 931703 (5 March 2015); doi: 10.1117/12.2080944; https://doi.org/10.1117/12.2080944

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