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5 March 2015 Photoacoustic biopsy: a feasibility study
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Abstract
Photoacoustic (PA) measurements encode the information associated with both physical microstructures and chemical contents in biological tissues. A two-dimensional physio-chemical spectrogram (PCS) can be formulated by combining the power spectra of PA signals acquired at a series of optical wavelengths. The analysis of PCS, or namely PA physio-chemical analysis (PAPCA), enables the quantification of the concentrations and the spatial distributions of a variety of chemical components in the tissue. The chemical components and their distribution are the two major features observed in the biopsy procedures which have been regarded as the gold standard of the diagnosis of many diseases. Taking non-alcoholic fatty liver disease and prostate cancer for example, this study investigates the feasibility of PAPCA in characterizing the histopathological changes in the diseased conditions in biological tissue. A catheter based setup facilitating measurement in deep tissues was also proposed and tested.
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Guan Xu, Scott A. Tomlins, Javed Siddiqui, Mandy Davis, Lakshmi P. Kunju, John T. Wei, and Xueding Wang "Photoacoustic biopsy: a feasibility study", Proc. SPIE 9318, Optical Biopsy XIII: Toward Real-Time Spectroscopic Imaging and Diagnosis, 931806 (5 March 2015); doi: 10.1117/12.2078068; https://doi.org/10.1117/12.2078068
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