Quantification of joint inflammation in rheumatoid arthritis by time-resolved diffuse optical spectroscopy and tracer kinetic modeling

Seva Ioussoufovitch; Laura B. Morrison; Ting-Yim Lee; Keith St. Lawrence; Mamadou Diop

doi:10.1117/12.2079811

5 March 2015 Quantification of joint inflammation in rheumatoid arthritis by time-resolved diffuse optical spectroscopy and tracer kinetic modeling

Seva Ioussoufovitch, Laura B. Morrison, Ting-Yim Lee, Keith St. Lawrence, Mamadou Diop

Author Affiliations +

Proceedings Volume 9319, Optical Tomography and Spectroscopy of Tissue XI; 93191D (2015) https://doi.org/10.1117/12.2079811
Event: SPIE BiOS, 2015, San Francisco, California, United States

Abstract

Rheumatoid arthritis (RA) is characterized by chronic synovial inflammation, which can cause progressive joint damage and disability. Diffuse optical spectroscopy (DOS) and imaging have the potential to become potent monitoring tools for RA. We devised a method that combined time-resolved DOS and tracer kinetics modeling to rapidly and reliably quantify blood flow in the joint. Preliminary results obtained from two animals show that the technique can detect joint inflammation as early as 5 days after onset.

Citation Download Citation

Seva Ioussoufovitch, Laura B. Morrison, Ting-Yim Lee, Keith St. Lawrence, and Mamadou Diop "Quantification of joint inflammation in rheumatoid arthritis by time-resolved diffuse optical spectroscopy and tracer kinetic modeling", Proc. SPIE 9319, Optical Tomography and Spectroscopy of Tissue XI, 93191D (5 March 2015); https://doi.org/10.1117/12.2079811

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