In vivo experimental validation for a featured-data time-domain diffuse fluorescence tomography based on the radiative transfer equation

Yan Zhang; Limin Zhang; Meng Jin; Huijuan Zhao; Feng Gao; Jiao Li

doi:10.1117/12.2075647

5 March 2015 In vivo experimental validation for a featured-data time-domain diffuse fluorescence tomography based on the radiative transfer equation

Yan Zhang, Limin Zhang, Meng Jin, Huijuan Zhao, Feng Gao, Jiao Li

Author Affiliations +

Proceedings Volume 9319, Optical Tomography and Spectroscopy of Tissue XI; 93191S (2015) https://doi.org/10.1117/12.2075647
Event: SPIE BiOS, 2015, San Francisco, California, United States

Abstract

In diffuse florescence tomography (DFT), the radiative transfer equation (RTE) and its P1 approximation, i.e. the diffuse equation (DE), have been used as the forward models. Since the assumptions of the diffusion approximation are not valid in particular regions of biological tissue which are close to the collimated light sources and boundaries, not scattering dominated or having void-like sub-domains, the RTE-based DFT methodology has become a focus of investigation. Therefore, we present a RTE-based featured-data scheme for time-domain DFT, which combines the discrete solidangle- element method and the finite element method to obtain numerical solutions of the Laplace-transformed 2D timedomain RTE, with the natural boundary condition and collimating light source model. The scheme is validated using the measurement data from phantom and in-vivo small-animal experiments compared to the DE-based scheme.

Citation Download Citation

Yan Zhang, Limin Zhang, Meng Jin, Huijuan Zhao, Feng Gao, and Jiao Li "In vivo experimental validation for a featured-data time-domain diffuse fluorescence tomography based on the radiative transfer equation", Proc. SPIE 9319, Optical Tomography and Spectroscopy of Tissue XI, 93191S (5 March 2015); https://doi.org/10.1117/12.2075647

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