11 March 2015 In vivo melanoma depth detection by a handheld photoacoustic microscope
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We developed a handheld photoacoustic microscope (PAM) to detect melanoma and determine tumor depth in nude mice in vivo. Compared to our previous PAM system for melanoma imaging, a new light delivery mechanism is introduced to improve light penetration. We show that melanomas with 4.1 mm and 3.3 mm thicknesses can be successfully detected in phantom and in vivo experiments, respectively. With its deep melanoma imaging ability and novel handheld design, this system is promising for clinical melanoma diagnosis, prognosis, and surgical planning for patients at the bedside.
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Yong Zhou, Yong Zhou, Wenxin Xing, Wenxin Xing, Konstantin I. Maslov, Konstantin I. Maslov, Lynn A. Cornelius, Lynn A. Cornelius, Lihong V. Wang, Lihong V. Wang, "In vivo melanoma depth detection by a handheld photoacoustic microscope", Proc. SPIE 9323, Photons Plus Ultrasound: Imaging and Sensing 2015, 932304 (11 March 2015); doi: 10.1117/12.2076684; https://doi.org/10.1117/12.2076684

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