Bone assessment via thermal photoacoustic measurements

Ting Feng; Kenneth M. Kozloff; Yi-Sing Hsiao; Chao Tian; Joseph Perosky; Sidan Du; Jie Yuan; Cheri X. Deng; Xueding Wang

doi:10.1117/12.2078228

11 March 2015 Bone assessment via thermal photoacoustic measurements

Ting Feng, Kenneth M. Kozloff, Yi-Sing Hsiao, Chao Tian, Joseph Perosky, Sidan Du, Jie Yuan, Cheri X. Deng, Xueding Wang

Author Affiliations +

Proceedings Volume 9323, Photons Plus Ultrasound: Imaging and Sensing 2015; 93231D (2015) https://doi.org/10.1117/12.2078228
Event: SPIE BiOS, 2015, San Francisco, California, United States

Abstract

The feasibility of an innovative biomedical diagnostic technique, thermal photoacoustic (TPA) measurement, for nonionizing and non-invasive assessment of bone health is investigated. Unlike conventional photoacoustic PA methods which are mostly focused on the measurement of absolute signal intensity, TPA targets the change in PA signal intensity as a function of the sample temperature, i.e. the temperature dependent Grueneisen parameter which is closely relevant to the chemical and molecular properties in the sample. Based on the differentiation measurement, the results from TPA technique is less susceptible to the variations associated with sample and system, and could be quantified with improved accurately. Due to the fact that the PA signal intensity from organic components such as blood changes faster than that from non-organic mineral under the same modulation of temperature, TPA measurement is able to objectively evaluate bone mineral density (BMD) and its loss as a result of osteoporosis. In an experiment on well established rat models of bone loss and preservation, PA measurements of rat tibia bones were conducted over a temperature range from 37⁰ C to 44⁰ C. The slope of PA signal intensity verses temperature was quantified for each specimen. The comparison among three groups of specimens with different BMD shows that bones with lower BMD have higher slopes, demonstrating the potential of the proposed TPA technique in future clinical management of osteoporosis.

Citation Download Citation

Ting Feng, Kenneth M. Kozloff, Yi-Sing Hsiao, Chao Tian, Joseph Perosky, Sidan Du, Jie Yuan, Cheri X. Deng, and Xueding Wang "Bone assessment via thermal photoacoustic measurements", Proc. SPIE 9323, Photons Plus Ultrasound: Imaging and Sensing 2015, 93231D (11 March 2015); https://doi.org/10.1117/12.2078228

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