11 March 2015 High-frequency photoacoustic imaging of erythrocyte aggregation and oxygen saturation: probing hemodynamic relations under pulsatile blood flow
Author Affiliations +
Abstract
In this paper, we investigate the feasibility of high-frequency photoacoustic (PA) imaging to study the shear rate dependent relationship between red blood cell (RBC) aggregation and oxygen saturation (SO2) in a simulated blood flow system. The PA signal amplitude increased during the formation of aggregates and cyclically varied at intervals corresponding to the beat rate (30, 60, 120, 180 and 240 bpm) for all optical wavelengths of illumination (750 and 850 nm).The SO2 also cyclically varied in phase with the PA signal amplitude for all beat rates. In addition, the mean blood flow velocity cyclically varied at the same interval of beat rate, and the shear rate (i.e. the radial gradient of flow velocity) also cyclically varied. On the other hand, the phase of the cyclic variation in the shear rate was reversed compared to that in the PA signal amplitude. This study indicates that RBC aggregation induced by periodic changes in the shear rate can be correlated with the SO2 under pulsatile blood flow. Furthermore, PA imaging of flowing blood may be capable of providing a new biomarker for the clinical application in terms of monitoring blood viscosity, oxygen delivery and their correlation.
© (2015) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
Tae-Hoon Bok, Eno Hysi, Michael C. Kolios, "High-frequency photoacoustic imaging of erythrocyte aggregation and oxygen saturation: probing hemodynamic relations under pulsatile blood flow", Proc. SPIE 9323, Photons Plus Ultrasound: Imaging and Sensing 2015, 93231Q (11 March 2015); doi: 10.1117/12.2076650; https://doi.org/10.1117/12.2076650
PROCEEDINGS
7 PAGES


SHARE
Back to Top