11 March 2015 Retrieving small features in reflection-mode raster-scan optoacoustic mesoscopy (RSOM) using multi-frequency reconstruction
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Abstract
We developed a reflection-mode, raster-scan optoacoustic mesoscopy system, based on a custom-made ultrasonic detector, with an ultra wide bandwidth of 20-180 MHz. To optimally use this bandwidth, we implemented multifrequency reconstruction. System characterization reveals a 4 μm axial, and 18 μm transverse resolution, at penetration depths reaching 5 mm. After characterization, the system was applied to image a zebrafish ex vivo, and an excised mouse ear. In the zebrafish, the lateral line, intestines, eyes, and melanocytes are seen, while in the mouse ear, multi-frequency reconstruction recovered the small vessels, otherwise not seen on the image.
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Murad Omar, Murad Omar, Dominik Soliman, Dominik Soliman, Jérôme Gateau, Jérôme Gateau, Vasilis Ntziachristos, Vasilis Ntziachristos, "Retrieving small features in reflection-mode raster-scan optoacoustic mesoscopy (RSOM) using multi-frequency reconstruction", Proc. SPIE 9323, Photons Plus Ultrasound: Imaging and Sensing 2015, 932326 (11 March 2015); doi: 10.1117/12.2076717; https://doi.org/10.1117/12.2076717
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