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11 March 2015 Photoacoustic physio-chemical analysis and its implementation in deep tissue with a catheter setup
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Abstract
Photoacoustic (PA) measurements encode the information associated with both physical microstructures and chemical contents in biological tissues. A two-dimensional physio-chemical spectrogram (PCS) can be formulated by combining the power spectra of PA signals acquired at a series of optical wavelengths. The analysis of PCS, or namely PA physio-chemical analysis (PAPCA), enables the quantification of the relative concentrations and the spatial distributions of a variety of chemical components in the tissue. This study validated the feasibility of PAPCA in characterizing liver conditions during the progression of non-alcoholic fatty liver disease. A catheter based setup facilitating measurement in deep tissues was also tested.
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Guan Xu, Zhou-xian Meng, Jian-die D. Lin, Qian Cheng, and Xueding Wang "Photoacoustic physio-chemical analysis and its implementation in deep tissue with a catheter setup", Proc. SPIE 9323, Photons Plus Ultrasound: Imaging and Sensing 2015, 93234F (11 March 2015); doi: 10.1117/12.2078063; https://doi.org/10.1117/12.2078063
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