Activity of glycated chitosan and other adjuvants to PDT vaccines

Mladen Korbelik; Judit Banáth; Evaldas Čiplys; Zdzislaw Szulc; Alicja Bielawska; Wei R. Chen

doi:10.1117/12.2077276

9 March 2015 Activity of glycated chitosan and other adjuvants to PDT vaccines

Mladen Korbelik, Judit Banáth, Evaldas Čiplys, Zdzislaw Szulc, Alicja Bielawska, Wei R. Chen

Proceedings Volume 9324, Biophotonics and Immune Responses X; 932407 (2015) https://doi.org/10.1117/12.2077276
Event: SPIE BiOS, 2015, San Francisco, California, United States

Abstract

Glycated chitosan (GC), a water soluble galactose-conjugated natural polysaccharide, has proven to be an effective immunoadjuvant for treatment of tumors based on laser thermal therapy. It was also shown to act as adjuvant for tumor therapy with high-intensity ultrasound and in situ photodynamic therapy (PDT). In the present study, GC was examined as potential adjuvant to PDT-generated cancer vaccine. Two other agents, pure calreticulin protein and acid ceramidase inhibitor LCL521, were also tested as prospective adjuvants for use in conjunction with PDT vaccines. Single treatment with GC, included with PDT vaccine cells suspension, improved the therapeutic efficacy when compared to vaccine alone. This attractive prospect of GC application remains to be carefully optimized and mechanistically elucidated. Both calreticulin and LCL521 proved also effective adjuvants when combined with PDT vaccine tumor treatment.

Citation Download Citation

Mladen Korbelik, Judit Banáth, Evaldas Čiplys, Zdzislaw Szulc, Alicja Bielawska, and Wei R. Chen "Activity of glycated chitosan and other adjuvants to PDT vaccines", Proc. SPIE 9324, Biophotonics and Immune Responses X, 932407 (9 March 2015); https://doi.org/10.1117/12.2077276

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