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9 March 2015 Treating cutaneous squamous cell carcinoma using ALA PLGA nanoparticle-mediated photodynamic therapy in a mouse model
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Proceedings Volume 9324, Biophotonics and Immune Responses X; 93240U (2015) https://doi.org/10.1117/12.2077939
Event: SPIE BiOS, 2015, San Francisco, California, United States
Abstract
Background: Squamous cell carcinoma (SCC) is a common skin cancer and its treatment is still difficult. The aim of this study was to evaluate the effectiveness of nanoparticle (NP)-assisted ALA delivery for topical photodynamic therapy (PDT) of cutaneous SCC.

Methods: UV-induced cutaneous SCCs were established in hairless mice. ALA loaded polylactic-co-glycolic acid (PLGA) NPs were prepared and characterized. The kinetics of ALA PLGA NPs-induced protoporphyrin IX (PpIX) fluorescence in SCCs, therapeutic efficacy of ALA NP-mediated PDT, and immune responses were examined.

Results: PLGA NPs could enhance PpIX production in SCC. ALA PLGA NP mediated topical PDT was more effective than free ALA of the same concentration in treating cutaneous SCC.

Conclusion: PLGA NPs provide a promising strategy for delivering ALA in topical PDT of cutaneous SCC.
© (2015) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
Xiaojie Wang, Lei Shi, Qingfeng Tu, Hongwei Wang, Haiyan Zhang, Peiru Wang, Linglin Zhang, Zheng Huang, Xiuli Wang, Feng Zhao, and Hansen Luan "Treating cutaneous squamous cell carcinoma using ALA PLGA nanoparticle-mediated photodynamic therapy in a mouse model", Proc. SPIE 9324, Biophotonics and Immune Responses X, 93240U (9 March 2015); https://doi.org/10.1117/12.2077939
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