6 March 2015 Fabricating optical phantoms to simulate skin tissue properties and microvasculatures
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Abstract
This paper introduces novel methods to fabricate optical phantoms that simulate the morphologic, optical, and microvascular characteristics of skin tissue. The multi-layer skin-simulating phantom was fabricated by a light-cured 3D printer that mixed and printed the colorless light-curable ink with the absorption and the scattering ingredients for the designated optical properties. The simulated microvascular network was fabricated by a soft lithography process to embed microchannels in polydimethylsiloxane (PDMS) phantoms. The phantoms also simulated vascular anomalies and hypoxia commonly observed in cancer. A dual-modal multispectral and laser speckle imaging system was used for oxygen and perfusion imaging of the tissue-simulating phantoms. The light-cured 3D printing technique and the soft lithography process may enable freeform fabrication of skin-simulating phantoms that embed microvessels for image and drug delivery applications.
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Shuwei Sheng, Qiang Wu, Yilin Han, Erbao Dong, Ronald Xu, "Fabricating optical phantoms to simulate skin tissue properties and microvasculatures", Proc. SPIE 9325, Design and Performance Validation of Phantoms Used in Conjunction with Optical Measurement of Tissue VII, 932507 (6 March 2015); doi: 10.1117/12.2086470; https://doi.org/10.1117/12.2086470
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