High-speed assessment of liquid viscoelasticity in flow cytometry using nonlinear Brillouin spectroscopy

Zhaokai Meng; Georgi I. Petrov; Vladislav V. Yakovlev

doi:10.1117/12.2079589

6 March 2015 High-speed assessment of liquid viscoelasticity in flow cytometry using nonlinear Brillouin spectroscopy

Zhaokai Meng, Georgi I. Petrov, Vladislav V. Yakovlev

Proceedings Volume 9327, Optical Elastography and Tissue Biomechanics II; 93270P (2015) https://doi.org/10.1117/12.2079589
Event: SPIE BiOS, 2015, San Francisco, California, United States

Abstract

Brillouin microspectroscopy is a powerful tool for elasticity-sensitive non-invasive optical imaging and sensing. However, spontaneous Brillouin spectroscopy usually requires long integration time, while its spectral quality is fundamentally limited by the optical setups. In this report, we demonstrated that nonlinear Brillouin spectroscopy based on impulsive stimulated Brillouin spectroscopy is capable of providing the necessary acquisition speed and spectral resolution of elasticity measurements. As a proof-of-principle, we demonstrated potential flow-cytometry applications.

Citation Download Citation

Zhaokai Meng, Georgi I. Petrov, and Vladislav V. Yakovlev "High-speed assessment of liquid viscoelasticity in flow cytometry using nonlinear Brillouin spectroscopy", Proc. SPIE 9327, Optical Elastography and Tissue Biomechanics II, 93270P (6 March 2015); https://doi.org/10.1117/12.2079589

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