11 March 2015 Performance evaluation for different sensing surface of BICELLs bio-transducers for dry eye biomarkers
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Biophotonic Sensing Cells (BICELLs) are demonstrated to be an efficient technology for label-free biosensing and in concrete for evaluating dry eye diseases. The main advantage of BICELLs is its capability to be used by dropping directly a tear into the sensing surface without the need of complex microfluidics systems. Among this advantage, compact Point of Care read-out device is employed with the capability of evaluating different types of BICELLs packaged on Biochip-Kits that can be fabricated by using different sensing surfaces material. In this paper, we evaluate the performance of the combination of three sensing surface materials: (3-Glycidyloxypropyl) trimethoxysilane (GPTMS), SU-8 resist and Nitrocellulose (NC) for two different biomarkers relevant for dry eye diseases: PRDX-5 and ANXA-11.
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M. F. Laguna, M. F. Laguna, M. Holgado, M. Holgado, B. Santamaría, B. Santamaría, A. López, A. López, M. Maigler, M. Maigler, A. Lavín, A. Lavín, J. de Vicente, J. de Vicente, J. Soria, J. Soria, T. Suarez, T. Suarez, C. Bardina, C. Bardina, M. Jara, M. Jara, F. J. Sanza, F. J. Sanza, R. Casquel, R. Casquel, A. Otón, A. Otón, T. Riesgo, T. Riesgo, "Performance evaluation for different sensing surface of BICELLs bio-transducers for dry eye biomarkers", Proc. SPIE 9337, Nanoscale Imaging, Sensing, and Actuation for Biomedical Applications XII, 93370J (11 March 2015); doi: 10.1117/12.2077174; https://doi.org/10.1117/12.2077174

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